Selected Immunosuppressants;Temsirolimus/Protease Inhibitors
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Protease inhibitors may slow down how quickly your body processes cyclosporine, sirolimus, tacrolimus, or temsirolimus.
What might happen:
The amount of cyclosporine, sirolimus, tacrolimus, or temsirolimus in your body may increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these two medicines together. Your doctor may want to check the amount of medicine in your blood.Contact your healthcare professional if you experience any chest discomfort, dizziness, shaking, leg cramping, swelling, or any unusual stomach upset, headache, or skin irritation.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Agenerase (amprenavir) Capsules US prescribing information. GlaxoSmithKline May, 2005.
2.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company January, 2013.
3.Victrelis (boceprevir) US prescribing information. Schering Corporation February, 2013.
4.Prezista (darunavir) US prescribing information. Tibotec Inc. February, 2013.
5.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline February, 2013.
6.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. February, 2011.
7.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.
8.Viracept (nelfinavir mesylate) US prescribing information. Agouron Pharmaceuticals, Inc. April, 2012.
9.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.
10.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. February, 2012.
11.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated December, 2012.
12.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. February, 2012.
13.Torisel (temsirolimus) US prescribing information. Wyeth Pharmaceuticals, Inc. June, 2011.
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19.Jain AK, Venkataramanan R, Shapiro R, Scantlebury VP, Potdar S, Bonham CA, Ragni M, Fung JJ. The interaction between antiretroviral agents and tacrolimus in liver and kidney transplant patients. Liver Transpl 2002 Sep;8(9):841-5.
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21.Jain AB, Venkataramanan R, Eghtesad B, Marcos A, Ragni M, Shapiro R, Rafail AB, Fung JJ. Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients. Liver Transpl 2003 Sep;9(9):954-60.
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25.Mertz D, Battegay M, Marzolini C, Mayr M. Drug-drug interaction in a kidney transplant recipient receiving HIV salvage therapy and tacrolimus. Am J Kidney Dis 2009 Jul;54(1):e1-4.