Selected Antiarrhythmics/Selected Protease Inhibitors
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Darunavir and lopinavir-ritonavir may slow down how quickly your liver processes amiodarone, lidocaine, and quinidine.
What might happen:
The amount of amiodarone, lidocaine, or quinidine in your blood may increase and cause life-threatening effects on your heart rhythm.
What you should do about this interaction:
Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check the amount of your antiarrhythmic in your blood. Your doctor may want to change the dose of your antiarrhythmic. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Prezista (darunavir) US prescribing information. Tibotec Inc. November, 2013.
2.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.