Rosuvastatin/Selected Protease Inhibitors
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Protease inhibitors may slow down how quickly your liver processes rosuvastatin.
What might happen:
The amount of rosuvastatin in your blood may increase and cause harmful effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any unexplained muscle pain, tenderness, weakness, or discoloration of your urine. Your doctor may want to change your cholesterol medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Crestor (rosuvastatin calcium) US prescribing information. AstraZeneca Pharmaceuticals LP December, 2012.
2.Crestor (rosuvastatin) UK summary of product characteristics. AstraZeneca UK Limited October 25, 2007.
3.Prezista (darunavir) US prescribing information. Tibotec Inc. February, 2013.
4.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline February, 2013.
5.Viracept (nelfinavir mesylate) US prescribing information. Agouron Pharmaceuticals, Inc. April, 2012.
6.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.
7.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. February, 2012.