My WebMD Sign In

Please enter email address

Enter your password

Keep me signed in on this computer

Show more Information

If you select "Keep me signed in on this computer", every time you visit WebMD.com you won't have to type your email address and password. This means that a cookie will stay on your computer even when you exit or close your browser which may reduce your levels of privacy and security. You should never select this option if you're using a publicly accessible computer, or if you're sharing a computer with others. Even if you select this option there are some features of our site that still require you to log in for privacy reasons.

Forget your password? Having trouble signing in?

Why should I
sign up for WebMD?

With a WebMD Account you can:

Track your way to weight loss success
Manage your family's vaccinations
Join the conversation

See more benefits Sign Up

Why WebMD?

My WebMD

Show Menu

Facebook Twitter Pinterest

WebMD Home

Drugs & Medications A-Z

Prilosec OTC Oral

Back to Drug Overview

Fda Alert from WebMD Medical News

FDA Warns of Fracture Risk From Acid Reflux Drugs

Does Prilosec OTC Oral interact with other medications?

Prilosec OTC Oral may interact with the following medications

Severe Interactions of Prilosec OTC Oral:
These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

PROTON PUMP INHIBITORS/RILPIVIRINE
PROTON PUMP INHIBITORS/ATAZANAVIR; NELFINAVIR

Serious Interactions of Prilosec OTC Oral:
These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

STRONG; SELECTED MODERATE CYP2C19 INHIBITORS/CLOBAZAM
PROTON PUMP INHIBITORS/METHOTREXATE (ONCOLOGY-INJECTION )
CYP2C19 INHIBITORS/CITALOPRAM (>20 MG)
PROTON PUMP INHIBITORS/MYCOPHENOLATE MOFETIL
ANTACIDS; H2 ANTAGONISTS; PROTON PUMP INHIBITORS/ULIPRISTAL
ESOMEPRAZOLE,OMEPRAZOLE,RABEPRAZOLE; CIMETIDINE/CLOPIDOGREL
H2 BLOCKERS; PPIS/BOSUTINIB; DASATINIB; ERLOTINIB; NILOTINIB
PROTON PUMP INHIBITORS/SELECTED AZOLE ANTIFUNGALS

Moderate Interactions of Prilosec OTC Oral:
These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

OMEPRAZOLE/VORICONAZOLE
SELECTED CYP2C19 INHIBITORS/ESCITALOPRAM (> OR = 20 MG)
ANTACIDS; H2 ANTAGONISTS; PROTON PUMP INHIBITORS/PONATINIB
H2 BLOCKERS;PPIS/CEFUROXIME AXETIL
SELECTED CYP2C19 INHIBITORS/CITALOPRAM (<= 20 MG)
SELECTED PROTON PUMP INHIBITORS/TACROLIMUS
PROTON PUMP INHIBITORS/METHOTREXATE(LOW STRENGTH INJ, ORAL)
H2 ANTAGONISTS; PROTON PUMP INHIBITORS/RALTEGRAVIR
ANTACIDS;H2 ANTAGONISTS;PROTON PUMP INHIBITORS/AMPHETAMINES
OMEPRAZOLE/HYDANTOINS
ESOMEPRAZOLE; OMEPRAZOLE/CILOSTAZOL

^ back to top

See 162 Reviews for this Drug. - OR -

Related to Prilosec OTC Oral

Conditions & Treatments Related to Prilosec OTC Oral

Treatment to Prevent Heartburn Medications

Condition in which Stomach Acid is Pushed Into the Esophagus Medications

Conditions of Excess Stomach Acid Secretion Medications

Inflammation of the Esophagus with Erosion Medications

Bleeding from Stomach, Esophagus or Duodenum Medications

See More

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

Pill Identifier

Learn about User Reviews and read IMPORTANT information about user generated content

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Drugs and Medications Center

Common Drugs

Vitamins & Supplements Center

First Aid Resources

Health Solutions From Our Sponsors

Vaccines for All Ages

FDA Protect Your Health

Benzocaine and Babies: Not a Good Mix
Database Is One-Stop Resource on Kids' Medications
Explore our expanded FDA Center on WebMD.

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Related Links

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.