Metoclopramide/SSRIs; SNRIs
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of your medicines increase serotonin levels in your blood. Also, some antidepressants may slow down how quickly your liver processes metoclopramide.
What might happen:
You may notice more irritability, double vision, nausea, confusion, anxiety, fever, increased muscle stiffness, or loss of consciousness.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you have any increase in irritability, double vision, nausea, confusion, anxiety, fever, increased muscle stiffness, or loss of consciousness.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Vlase L, Leucuta A, Farcau D, Nanulescu M. Pharmacokinetic interaction between fluoxetine and metoclopramide in healthy volunteers. Biopharm Drug Dispos 2006 Sep;27(6):285-9.
2.Coulter DM, Pillans PI. Fluoxetine and extrapyramidal side effects. Am J Psychiatry 1995 Jan;152(1):122-5.
3.Palop V, Jimenez MJ, Catalan C, Martinez-Mir I. Acute dystonia associated with fluvoxamine-metoclopramide. Ann Pharmacother 1999 Mar;33(3):382.
4.Christensen RC, Byerly MJ. Mandibular dystonia associated with the combination of sertraline and metoclopramide. J Clin Psychiatry 1996 Dec; 57(12):596.
5.Vandemergel X, Beukinga I, Neve P. Serotonin syndrome secondary to the use of sertraline and metoclopramide. Rev Med Brux 2000 Jun;21(3):161-3.
6.Fisher AA, Davis MW. Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction. Ann Pharmacother 2002 Jan; 36(1):67-71.
