How the interaction occurs:
Beta-blockers may block the effects of epinephrine.
What might happen:
Taking beta-blockers with epinephrine may cause your blood pressure to be increased. Your heart rate may slow down.The effect of epinephrine on severe allergic reactions may be decreased if you are also taking beta-blockers.
What you should do about this interaction:
Avoid taking these medications together. If they are taken together, your blood pressure and heart rate should be closely monitored. If you carry epinephrine as a precaution against allergic reactions, discuss the fact that you are also taking a beta-blocker with your doctor and what to do in the event of an emergency situation.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Ichinohe T, Igarashi O, Kaneko Y. The influence of propranolol on the cardiovascular effects and plasma clearance of epinephrine. Anesth Prog 1991 Nov-Dec;38(6):217-20.
2.Mackie K, Lam A. Epinephrine-containing test dose during beta-blockade. J Clin Monit 1991 Jul;7(3):213-6.
3.Houben H, Thien T, De Boo T, Lemmens W, Van Herwaarden CL, Fennis JF, Van 't Laar A. Influence of selective and non-selective beta-adrenoreceptor blockade on the haemodynamic effect of adrenaline during combined antihypertensive drug therapy. Clin Sci (Lond) 1979 Dec;57 Suppl 5:397s-399s.
4.Newman BR, Schultz LK. Epinephrine-resistant anaphylaxis in a patient taking propranolol hydrochloride. Ann Allergy 1981 Jul;47(1):35-7.