Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Metoclopramide decreases the amount of atovaquone your body absorbs.
What might happen:
The amount of atovaquone in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to perform blood tests to see if your medicine is working. Your doctor may want you try a different medicine to prevent vomiting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Malarone (atovaquone-proguanil) UK summary of product characteristics. GlaxoSmithKline UK August 6, 2012.
2.Malarone (atovaquone and proguanil hydrochloride) US prescribing information. GlaxoSmithKline March, 2010.
3.Barnett ED. Drug-Vaccine & Drug-Drug Interactions. CDC Health Information for International Travel 2012 (The Yellow Book) available at: http://wwwnc.cdc.gov/travel/yellowbook/2012/chapter-2-the-pre-travel-consu ltation/drug-vaccine-and-drug-drug-interactions.htm July 6, 2011.