Skip to content
My WebMD Sign In, Sign Up

sulindac oral

ACE Inhibitors; ARBs/NSAIDs

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known.

What might happen:

The effects of your blood pressure medicine may decrease. Your blood pressure may increase, causing headache, dizziness, or blurred vision. Your kidneys may not work as well.

What you should do about this interaction:

If your blood pressure does increase, contact your doctor. It may be necessary to change the dosage of your blood pressure medicine or change your pain medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Swartz SL, Williams GH. Angiotensin-converting enzyme inhibition and prostaglandins. Am J Cardiol 1982 Apr 21;49(6):1405-9.
2.Cleary JD, Taylor JW. Enalapril: a new angiotensin converting enzyme inhibitor. Drug Intell Clin Pharm 1986 Mar;20(3):177-86.
3.Abe K, Ito T, Sato M, Haruyama T, Sato K, Omata K, Hiwatari M, Sakurai Y, Imai Y, Yoshinaga K. Role of prostaglandin in the antihypertensive mechanism of captopril in low renin hypertension. Clin Sci (Lond) 1980 Dec;59 Suppl 6:141s-144s.
4.Abe K, Itoh T, Imai Y, Sato M, Goto T, Otsuka Y, Yoshinaga K. Indomethacin inhibits the antihypertensive effect of captopril, SQ 14225, in low renin hypertension. Tohoku J Exp Med 1980 Sep;132(1):117-8.
5.Moore TJ, Crantz FR, Hollenberg NK, Koletsky RJ, Leboff MS, Swartz SL, Levine L, Podolsky S, Dluhy RG, Williams GH. Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension. Hypertension 1981 Mar-Apr;3(2):168-73.
6.Fujita T, Yamashita N, Yamashita K. Effect of indomethacin on antihypertensive action of captopril in hypertensive patients. Clin Exp Hypertens 1981;3(5):939-52.
7.Ogihara T, Maruyama A, Hata T, Mikami H, Nakamaru M, Naka T, Ohde H, Kumahara Y. Hormonal responses to long-term converting enzyme inhibition in hypertensive patients. Clin Pharmacol Ther 1981 Sep;30(3):328-35.
8.Silberbauer K, Stanek B, Templ H. Acute hypotensive effect of captopril in man modified by prostaglandin synthesis inhibition. Br J Clin Pharmacol 1982;14 Suppl 2:87S-93S.
9.Salvetti A, Pedrinelli R, Magagna A, Ugenti P. Differential effects of selective and non-selective prostaglandin-synthesis inhibition on the pharmacological responses to captopril in patients with essential hypertension. Clin Sci 1982;63(Suppl 8):261s-3s.
10.Gilchrist NL, Richards AM, March R, Nicholls MG. Effect of sulindac on angiotensin converting enzyme inhibitor-induced cough: randomised placebo-controlled double-blind cross-over study. J Hum Hypertens 1989 Dec;3(6):451-5.
11.Ohya Y, Kumamoto K, Fujishima M. Effects of crossover application of sulindac and azelastine on enalapril-induced cough. J Hum Hypertens 1992 Feb;6(1):81-2.
12.Allon M, Pasque CB, Rodriguez M. Interaction of captopril and ibuprofen on glomerular and tubular function in humans. Am J Physiol 1990 Aug;259(2 Pt 2):F233-8.
13.Allon M, Pasque CB, Rodriguez M. Acute effects of captopril and ibuprofen on proteinuria in patients with nephrosis. J Lab Clin Med 1990 Oct; 116(4):462-8.
14.Minuz P, Lechi A, Arosio E, Degan M, Capuzzo MG, Lechi C, Corsato M, Dalla Riva A, Velo GP. Antihypertensive activity of enalapril. Effect of ibuprofen and different salt intakes. J Clin Hypertens 1987 Dec; 3(4):645-53.
15.Polonia J, Boaventura I, Gama G, Camoes I, Bernardo F, Andrade P, Nunes JP, Brandao F, Cerqueira-Gomes M. Influence of non-steroidal anti-inflammatory drugs on renal function and 24h ambulatory blood pressure-reducing effects of enalapril and nifedipine gastrointestinal therapeutic system in hypertensive patients. J Hypertens 1995 Aug; 13(8):925-31.
16.Morgan TO, Anderson A, Bertram D. Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. Am J Hypertens 2000 Nov;13(11):1161-7.
17.Conlin PR, Moore TJ, Swartz SL, Barr E, Gazdick L, Fletcher C, DeLucca P, Demopoulos L. Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients. Hypertension 2000 Sep; 36(3):461-5.
18.Fricker AF, Nussberger J, Meilenbrock S, Brunner HR, Burnier M. Effect of indomethacin on the renal response to angiotensin II receptor blockade in healthy subjects. Kidney Int 1998 Dec;54(6):2089-97.
19.Morgan T, Anderson A. Interaction of indomethacin with felodipine and enalapril. J Hypertens Suppl 1993 Dec;11 Suppl 5:S338-9.
20.Halawa B. Effect of indomethacin and ibuprofen on blood pressure of patients treated with nifedipine or captopril. Pol Tyg Lek 1993 Apr 5-12; 48(14-15):313-5.
21.Espino DV, Lancaster MC. Neutralization of the effects of captopril by the use of ibuprofen in an elderly woman. J Am Board Fam Pract 1992 May-Jun;5(3):319-21.
22.Abdel-Haq B, Magagna A, Favilla S, Salvetti A. Hemodynamic and humoral interactions between perindopril and indomethacin in essential hypertensive subjects. J Cardiovasc Pharmacol 1991;18 Suppl 7:S33-6.
23.Heeg JE, de Jong PE, de Zeeuw D. Additive antiproteinuric effect of angiotensin-converting enzyme inhibition and non-steroidal anti-inflammatory drug therapy: a clue to the mechanism of action. Clin Sci (Lond) 1991 Sep;81(3):367-72.
24.Kirch W, Stroemer K, Hoogkamer JF, Kleinbloesem CH. The influence of prostaglandin inhibition by indomethacin on blood pressure and renal function in hypertensive patients treated with cilazapril. Br J Clin Pharmacol 1989;27 Suppl 2:297S-301S.
25.Fogari R, Zoppi A, Carretta R, Veglio F, Salvetti A. Effect of indomethacin on the antihypertensive efficacy of valsartan and lisinopril: a multicentre study. J Hypertens 2002 May;20(5):1007-14.
26.Phansalkar S, van der Sijs H, Tucker AD, Desai AA, Bell DS, Teich JM, Middleton B, Bates DW. Drug-drug interactions that should be non-interruptive in order to reduce alert fatigue in electronic health records. J Am Med Inform Assoc 2012 Sep 25.
27.Prlesi L, Plakogiannis R. Angioedema after nonsteroidal antiinflammatory drug initiation in a patient stable on an angiotensin-converting-enzyme inhibitor. Am J Health Syst Pharm 2010 Aug 15;67(16):1351-3.
28.Kampitak T. Recurrent severe angioedema associated with imidapril and diclofenac. Allergol Int 2008 Dec;57(4):441-3.

See 64 Reviews for this Drug. - OR -

Review this Treatment

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

(for example: aspirin)

(for example: diabetes)

Report Problems to the Food and Drug Administration
 
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Health Solutions From Our Sponsors

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Ask a Question

Popular Slideshows & Tools on WebMD

tea
What you should eat.
Woman sitting in front of UV lights
Is yours working?
woman using breath spray
What's causing yours?
colon xray
Get the facts.
MS Overview
Recognizing symptoms.
bowl of yogurt with heart shape
Eat for a healthy heart.
woman doing pushups
To help you get fit.
Colored x-ray of tooth decay
Know what to look for.
Woman sitting with child
Do you know the symptoms?
fruit drinks
Foods that can help you focus.
Sad dog and guacamole
Don't feed this to your dog.
Thyroid exam
See how much you know.

Women's Health Newsletter

Find out what women really need.

WebMD the app

Get trusted health information. Whenever. Wherever... with your iPhone, iPad or Android.

Find Out More

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.