Atorvastatin (> 20 mg); Pravastatin (> 40 mg)/Clarithromycin
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process your cholesterol medicine properly.
What might happen:
The blood levels of your cholesterol medicine may increase and cause toxic effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may instruct you to stop taking your cholesterol medicine while taking your antibiotic or adjust the dose of your cholesterol medicine.Tell your doctor right away if you experience muscle pain, tenderness, or weakness; unexplained tiredness; or discolored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Lipitor (atorvastatin) US prescribing information. Pfizer Inc. October, 2012.
2.Pravachol (pravastatin sodium) US prescribing information. Bristol-Myers Squibb Company October, 2012.
3.Jacobson TA. Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors. Am J Cardiol 2004 Nov 1;94(9):1140-6.