Ixabepilone/Strong CYP3A4 Inhibitors
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may slow down how quickly your liver processes ixabepilone.
What might happen:
The amount of ixabepilone in your blood may increase and cause more side effects than normally expected.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust the dose of your ixabepilone during and for one week after you stop taking your other medicine. Your doctor may want to check the amounts of cells in your blood more often while you are taking these medicines together. Be sure to keep all of your laboratory appointments. Let your doctor know right away if you develop numbness/tingling/burning of the hands or feet; if you have any signs of infections such as fever, chills, cough, or burning/pain when you urinate; or signs of heart problems such as chest pain, difficulty breathing, palpitations, or unusual weight gain.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Ixempra (ixabepilone) US prescribing information. Bristol-Myers Squibb Company October, 2011.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.