Lovastatin (<= 20 mg)/Danazol
How the interaction occurs:
Danazol may slow down how quickly your liver processes your cholesterol medicine.
What might happen:
The amount of cholesterol medicine in your blood may increase and damage your muscles.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to lower your dose of your cholesterol medicine.Tell your doctor right away if you experience muscle pain, tenderness, or weakness; unexplained tiredness; or discolored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Mevacor (lovastatin) US prescribing information. Merck & Co., Inc. February, 2012.
2.Hsieh CY, Chen CH. Rhabdomyolysis and pancreatitis associated with coadministration of danazol 600 mg/d and lovastatin 40 mg/d. Clin Ther 2008 Jul;30(7):1330-5.
3.Khanna S, Mundell WC. Rhadbomyolysis associated with co-administration of danazol and lovastatin. Br J Clin Pharmacol 2011 Jul;72(1):166-7.
4.Dallaire M, Chamberland M. Severe rhabdomyolysis in a patient receiving lovastatin, danazol, and doxycycline. CMAJ 1994 Jun 15;150(12):1991-4.