Solifenacin/Nelfinavir; Ritonavir (mono deleted 04/05/2012)
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nelfinavir and ritonavir may slow down how quickly your liver processes solifenacin.
What might happen:
The amount of solifenacin in your blood may increase and cause more side effects than it normally does. The effects may be more severe if you have kidney or liver problems.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking your medicines together and if you have any problems with your kidneys or liver. Let your doctor know if you have any problems with dry mouth, nausea, upset stomach, abdominal pain, blurred vision, headaches, drowsiness, hallucinations, excitation, seizures, fast heartbeat, trouble breathing, or if you stop urinating or have difficulty urinating.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Vesicare (solifenacin succinate) UK summary of product characteristics. Yamanouchi Pharma Ltd. August 16, 2004.