Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Protease inhibitors may slow down how quickly your liver processes tadalafil.
What might happen:
Your blood levels of tadalafil may increase and cause harmful effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Contact your doctor if you experience a painful or prolonged erection, fainting or dizziness, or changes in vision. The dose of your tadalafil may need adjusting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Cialis (tadalafil) US prescribing information. Eli Lilly and Company February, 2010.
2.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company August, 2013.
3.Prezista (darunavir) US prescribing information. Tibotec Inc. November, 2013.
4.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline February, 2013.
5.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. February, 2011.
6.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.
7.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.
8.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. February, 2012.
9.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. February, 2012.
10.Viracept (nelfinavir mesylate) US prescribing information. Agouron Pharmaceuticals, Inc. May, 2013.