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pancuronium intravenous

General Anesthetics (Inhl)/Neuromuscular Blocking Agents

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the effects of the muscle relaxant may increase.

What might happen:

The intentional blocking of transmission to nerve and muscle by the muscle relaxant medicine may be increased or prolonged.

What you should do about this interaction:

These medicines are used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Miller RD, Eger EI 2nd, Way WL, Stevens WC, Dolan WM. Comparative neuromuscular effects of Forane and halothane alone and in combination with d-tubocurarine in man. Anesthesiology 1971 Jul;35(1):38-42.
2.Miller RD, Way WL, Dolan WM, Stevens WC, Eger EI 2nd. Comparative neuromuscular effects of pancuronium, gallamine, and succinylcholine during forane and halothane anesthesia in man. Anesthesiology 1971 Nov; 35(5):509-14.
3.Miller RD, Way WL, Dolan WM, Stevens WC, Eger EI 2nd. The dependence of pancuronium- and d-tubocurarine-induced neuromuscular blockades on alveolar concentrations of halothane and forane. Anesthesiology 1972 Dec; 37(6):573-81.
4.Fogdall RP, Miller RD. Neuromuscular effects of enflurane, alone and combined with d- Tubocurarine, pancuronium, and succinylcholine, in man. Anesthesiology 1975 Feb;42(2):173-8.
5.Vitez TS. Potency of metocurine during halothane-N2O and N2O-narcotic anesthesia. Anesth Analg 1978 Jan-Feb;57(1):116-7.
6.Sebel PS, Bovill JG, Wauquier A, Rog P. Effects of high-dose fentanyl anesthesia on the electroencephalogram. Anesthesiology 1981 Sep; 55(3):203-11.
7.Artru AA, Nugent M, Michenfelder JD. Enflurane causes a prolonged and reversible increase in the rate of CSF production in the dog. Anesthesiology 1982 Oct;57(4):255-60.
8.Stirt JA, Katz RL, Murray AL, Schehl DL, Lee C. Modification of atracurium blockade by halothane and by suxamethonium. A review of clinical experience. Br J Anaesth 1983;55 Suppl 1:71S-75S.
9.Brandom BW, Cook DR, Woelfel SK, Rudd GD, Fehr B, Lineberry CG. Atracurium infusion requirements in children during halothane, isoflurane, and narcotic anesthesia. Anesth Analg 1985 May;64(5):471-6.
10.Rupp SM, Miller RD, Gencarelli PJ. Vecuronium-induced neuromuscular blockade during enflurane, isoflurane, and halothane anesthesia in humans. Anesthesiology 1984 Feb;60(2):102-5.
11.Ostergaard D, Engbaek J, Viby-Mogensen J. Adverse reactions and interactions of the neuromuscular blocking drugs. Med Toxicol Adverse Drug Exp 1989 Sep-Oct;4(5):351-68.
12.Swen J, Rashkovsky OM, Ket JM, Koot HW, Hermans J, Agoston S. Interaction between nondepolarizing neuromuscular blocking agents and inhalational anesthetics. Anesth Analg 1989 Dec;69(6):752-5.
13.Withington DE, Donati F, Bevan DR, Varin F. Potentiation of atracurium neuromuscular blockade by enflurane: time- course of effect. Anesth Analg 1991 Apr;72(4):469-73.

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