Propafenone/Grapefruit Juice Interaction
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
Propafenone is processed by enzymes in your intestine. Grapefruit and grapefruit juice contain compounds that slow down this process.
What might happen:
The level of propafenone in your blood can increase in your blood and may cause changes in your heart's rhythm.
What you should do about this interaction:
While you are taking this medicine, you should avoid eating grapefruit or drink grapefruit juice. You may choose an alternative citrus beverage (such as orange juice).In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with doctor the effects of grapefruit on the blood levels of this medicine. If you notice an increase in any side effect from your medicine, contact your doctor. If you notice new or worsened abnormal heart beats or new or increased swelling in your arms or legs, have trouble breathing, or experience sudden weigh gain, contact your doctor right away.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.Reference:1.Rythmol (propafenone hydrochloride) US prescribing information. Abbott Laboratories March, 2013.