Fentanyl/MAOIs
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is unknown.
What might happen:
You may experience weakness, fatigue, drowsiness, and extremely high fever. This reaction may be life threatening.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
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4.Noble WH, Baker A. MAO inhibitors and coronary artery surgery: a patient death. Can J Anaesth 1992 Dec;39(10):1061-6.
5.DBL fentanyl injection Australian prescribing information. FH Faulding & Co Limited t/a David Bull Laboratories October 31, 2003.
6.Actiq (fentanyl citrate) Australian prescribing information. Orphan Australia Pty Ltd. November 2, 2002.
7.Actiq (fentanyl citrate) US prescribing information. Cephalon, Inc. July, 2011.
8.Duragesic (fentanyl) US prescribing information. Janssen Pharmaceuticals, Inc. July, 2012.
9.Sublimaze (fentanyl citrate) US prescribing information. Taylor Pharmaceuticals 2005.
10.Ramsay RR, Dunford C, Gillman PK. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol 2007 Nov;152(6):946-51.
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