Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Antimalarials can affect your heart's rhythm
What might happen:
The rhythm of your heart may change and this may be life-threatening.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) right away about taking these medicines together. Your doctor may want to change your medicine. Let your doctor know if you have recently taken other antimalarial agents such as halofantrine or quinine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Riamet (artemether/lumefantrine) UK summary of product characteristics. Novartis Pharmaceuticals UK Ltd. June 27, 2001.
2.Coartem (artemether/lumefantrine) US prescribing information. Novartis Pharmaceuticals Corporation April, 2013.
3.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.