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nicardipine intravenous

Digoxin/Calcium Channel Blockers

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process digoxin properly.

What might happen:

The blood levels of digoxin may increase and cause toxic effects.

What you should do about this interaction:

If you experience nausea, vomiting, diarrhea, loss of appetite, slow or irregular heartbeat, or vision changes (e.g. blurred vision or yellow/ green halos around objects), contact your doctor. You may need to have your blood level of digoxin checked, and your dose may need to be adjusted.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


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3.Oyama Y, Fujii S, Kanda K, Akino E, Kawasaki H, Nagata M, Goto K. Digoxin-diltiazem interaction. Am J Cardiol 1984 May 15;53(10):1480-1.
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10.Schrager BR, Pina I, Frangi M, Applewhite S, Sequeira R, Chahine RA. Diltiazem, digoxin interaction?. Circulation 1983 Oct;68(Suppl III):III-368.
11.Jones WN, Kern KB, Rindone JP, Mayersohn M, Bliss M, Goldman S. Digoxin-diltiazem interaction: a pharmacokinetic evaluation. Eur J Clin Pharmacol 1986;31(3):351-3.
12.Boden WE, More G, Sharma S, Bough EW, Korr KS, Young PM, Shulman RS. No increase in serum digoxin concentration with high-dose diltiazem. Am J Med 1986 Sep;81(3):425-8.
13.Johnson BF, Wilson J, Marwaha R, Hoch K, Johnson J. The comparative effects of verapamil and a new dihydropyridine calcium channel blocker on digoxin pharmacokinetics. Clin Pharmacol Ther 1987 Jul;42(1):66-71.
14.Rodin SM, Johnson BF, Wilson J, Ritchie P, Johnson J. Comparative effects of verapamil and isradipine on steady-state digoxin kinetics. Clin Pharmacol Ther 1988 Jun;43(6):668-72.
15.Rehnqvist N, Billing E, Moberg L, Lundman T, Olsson G. Pharmacokinetics of felodipine and effect on digoxin plasma levels in patients with heart failure. Drugs 1987;34 Suppl 3:33-42.
16.Dunselman PH, Scaf AH, Kuntze CE, Lie KI, Wesseling H. Digoxin-felodipine interaction in patients with congestive heart failure. Eur J Clin Pharmacol 1988;35(5):461-5.
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20.Lanoxin (digoxin) Tablets US prescribing information. GlaxoSmithKline August, 2012.

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