Show ratings & reviews for

3.3 Overall Rating

Effectiveness

Ease of Use

Satisfaction

Most voted positive review

61 People found this comment helpful

My atrophy was so bad that I couldn't sit comfortably. Premarin cream did nothing. Osphena is a miracle for me. But Medicare won't cover it! It's made for Senior women so it's foolish that Medicare doesn't cover it. Medicare covers Viagra! Are Senior men supposed to have sex with 30 year old women?

Most voted negative review

13 People found this comment helpful

I chose a new GYN Dr. due to the fact that I felt I was not getting the help I was asking for based on extremely painful intercourse. My new Dr. put me on Osphena, and after being on it for 10 days, I realized that I was having extreme anxiety, but I did not relate it to this medication. I suffer from severe depression, and I just thought it had been a really tough year in ALL aspects of my life. ...

Shared reviews and ratings

Anonymous | 65-74 | Female |
2/7/2024
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

10 years on this drug. Painful intercourse gone. Lots of vaginal wetness,,,sometimes too wet. No side effects. 90 day supply through Humana cost $141.00 I am 74....look 45 and date men from 23 to 50. 5'9" size 6 No immediate weight gain....but I always watch my weight and exercise.

Report this postFill 3Created with Sketch.
Kb | 45-54 | Female | On medication for 10 years or more | Patient
1/4/2024
Condition: Other
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I had a total hysterectomy at 42 put me straight into menopause and within atrophy. Because breast cancer runs in my family my gynecologist put me on Opina to prevent me from having higher chances of breast cancer. Been on it for 13 years it is a game changer. I still have somewhat painful sex just because I don’t have it very often, but I do not have any Vaginal dryness and after 13 yrs is use my doctor says I look completely normal for my age. It’s a life changer! My insurance won’t pay for it but I go on their website and get 90. Supple for $250. It’s worth it! Thank god for this medication. My OBGYN said it deters Breast cancer too. Read More Read Less

Report this postFill 3Created with Sketch.
Disappointed | 55-64 | Female | On medication for 1 to 6 months | Patient
12/2/2023
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 2.3
Effectiveness
Ease of Use
Satisfaction

I started taking this medication 6/2023 for all the reasons mentioned by other reviews. I have had a terrible experience with its side effects and it hasn’t helped the symptoms for which it was prescribed! I took 22 of a 30 pill prescription. I stopped when I had the first yeast infection that I now know was caused from this drug! Annoying vaginal discharge daily, still having this and stopped the drug 2months ago. Had second yeast infection since off the medication which is costly and terribly uncomfortable. I also finally figured out that my weight gain was caused from this drug. 7-10 lbs. and I had been eating less carbs and on an exercise regimen. Can’t shed the pounds. I had no good experience with this drug. Would not recommend. Also, shame on my Gyn doctor for not discussing these potential problems with me. Read More Read Less

Report this postFill 3Created with Sketch.
Bernadette555 | 65-74 | Female | On medication for 2 to less than 5 years | Patient
8/21/2023
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 4.3
Effectiveness
Ease of Use
Satisfaction

I take Osphena three times a week and it's decreased intercourse pain about 50-75%. I can't take it every day because it works TOO well - I almost feel like a dog in heat! I haven't experienced any of the side effects mentioned in the other comments; maybe that's because I'm not taking it every day.

Report this postFill 3Created with Sketch.
Julie | 45-54 | Female | On medication for 6 months to less than 1 year | Patient
12/27/2022
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 2.7
Effectiveness
Ease of Use
Satisfaction

At first I thought this was a new wonder drug , 6 months on it weight gain, hair loss , super bad leg cramps , trouble sleeping. Went to get a refill and my insurance wouldn't cover it . Been off it for two weeks now full blown period bleeding, bad migraine, bad cramping, breast pain, hot flashes ....can't get into the doctors because of holidays and it's freaking me out...not worth it !!

Report this postFill 3Created with Sketch.
Unhappy Lady | 55-64 | Female | On medication for 6 months to less than 1 year | Patient
8/30/2022
Condition: Other
Overall rating 3.7
Effectiveness
Ease of Use
Satisfaction

I was put on this med due to painful intercourse not only for menopause but due to the total hysterectomy, removal of tubes and ovaries. Before taking this medication, my dryness was so bad that I would actually have a small amount of blood on my pantyliner after intercourse. I will have to find something else because my insurance will not pay for it now, but this may be a good thing due to the side effects I am dealing with: 1) Weight gain; I have gained about 10 lbs. in less than a year 2) Severe muscle cramps in my legs. This is even during the day 3) Lethargic - tired and not interested in doing the day-to-day things. Sometimes I even fall asleep watching a movie 3) Moodiness - like it doesn't take much to make me cry 4) Hot flashes - not often but due to my age and being through menopause for years, I feel like I am backtracking 5) Sometimes I just feel hot all the time Hopefully the next med will help me, but I will not have all the side effects.Read More Read Less

Report this postFill 3Created with Sketch.
60somethinglady | 55-64 | Female | On medication for 2 to less than 5 years | Patient
8/18/2022
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 2.3
Effectiveness
Ease of Use
Satisfaction

My gynecologist put me on this 3 years ago for vaginal atrophy (what a lovely term, right ladies?) and told me to give it 4-6 months before I'd see even the slightest change - HA! During the last 3 years, I've experienced nothing but weight gain, a few more nights of waking up sweating and even though she has nothing but try to convince me to stay on the medicine - I'M DONE WITH IT! I've had much better luck with Estradiol cream. No fun inserting that cream twice a week vaginally, but at least it's working. I have Multiple Sclerosis and was concerned some of my issue was due to nerve problems from that, thankfully it isn't! My neurologist sent me to a pelvic floor physical therapist - who knew that even existed!?!?!? THAT HAS MADE ALL THE DIFFERENCE IN THE WORLD! No pain, no issues and a wonderful sex life again with my amazing husband!Read More Read Less

Report this postFill 3Created with Sketch.
Allyson | 55-64 | Female | On medication for 2 to less than 5 years | Patient
7/1/2022
Condition: Vaginal Inflammation due to Loss of Hormone Stimulation
Overall rating 3.7
Effectiveness
Ease of Use
Satisfaction

I've been taking this for a couple of years. It definitely helped the dry, itchiness but yes I have put on weight that I can't get rid of. I'm 57, went thru menopause in my late 40's, gained some weight but lost it so all was ok. Then I started this because I couldn't do hormone replacement due to blood clots, and my estrogen bottomed out. Gained weight I can't get rid of. Got to reading about the osphena and I don't understand why I was put on it with what it says about clots. I'm on blood thinner for goodness sakes !! I ran out nearly a week ago, and hadn't refilled. I am so tired,so sleepy all day. Have had sleeping problems for couple years and been treating depression for over 20 years and the Dr has all this in my chart......so why have I been taking this ? I have AFib, one of the reasons for the blood thinner . From what I've read I shouldn't have been on this at all.Read More Read Less

Report this postFill 3Created with Sketch.
Concerned | 55-64 | Female | On medication for 2 to less than 5 years | Patient
10/1/2021
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 4.3
Effectiveness
Ease of Use
Satisfaction

This drug was/is a miracle when it comes to stopping painful intercourse and vaginal dryness. It also helped with my frequent UTIs. However... I have found if I miss a day or 2 my moods become very depressed. Has anyone else experienced this? Great as long as I take it but I'm worried about what might happen if I can't get or afford this med anymore. I have never needed antidepressants before. It concerns me.

Report this postFill 3Created with Sketch.
Quirky Patient | Female | On medication for 5 to less than 10 years | Patient
9/3/2021
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I was the first patient to ask my doctor about Osphena, but I certainly wasn’t the last. Menopause had done a number on me, and my marriage’s sex life was in the toilet due to pain and dryness. I’ve been on this medication for six years. I will never go without it. I cannot use estrogen. This medication has meant I could choose happiness despite menopause.

Report this postFill 3Created with Sketch.
Maddie | 55-64 | On medication for 1 to less than 2 years | Patient
7/15/2021
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 3.3
Effectiveness
Ease of Use
Satisfaction

Testosterone works way way way better, is safer, and doesn’t cause weight gain like Osphena does. Testosterone is a game changer! I gained much weight on Osphena and while it definitely got rid of vaginal dryness, it did nothing else. Testosterone has many beneficial effects! Stupid American doctors need to get with the program. Thank goodness, my gyn is enlightened!

Report this postFill 3Created with Sketch.
Anonymous | 55-64 | Female | On medication for less than 1 month | Patient
2/8/2020
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 2.7
Effectiveness
Ease of Use
Satisfaction

I have only been on this drug for one week and have gained 3 pounds with no change in diet or exercise routine. Since I lost 10 pounds last year and now I'm at a weight I haven't seen since 8 months ago, I am very displeased. Also, it cost me $100. Of course I have not been taking it long enough to see if it could help with my vaginal issues but I don't think I want to see how much weight I'm likely to gain so considering stopping it now.

Report this postFill 3Created with Sketch.
Sweaty Betty | 55-64 | On medication for 1 to 6 months | Patient
12/2/2019
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 4.3
Effectiveness
Ease of Use
Satisfaction

Can you say hot flashes, night sweats, weight gain, foot and leg pain, diarrhea and cramping, acne, itching, and moodiness? Oh, it works in the reducing pain and lubricating department, but my libido is still non-existent. Hubby is happy, but I could really do without all the side effects. And now I am having extreme heartburn. I came here to see if anyone else is having that as a side effect and saw all the other side effects I have been having enumerated in nearly every review. Is it worth it? For my husband it is. If it werenâ??t for him I would chuck this medicine today and save my money for a gym membership to try to dump this awful weight gain.Read More Read Less

Report this postFill 3Created with Sketch.
AMA | 45-54 | On medication for 1 to 6 months | Patient
9/23/2019
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 3.7
Effectiveness
Ease of Use
Satisfaction

Very effective for symptoms. However, gained 6 pounds almost instantly, hot flashes and night sweats returned with a vengeance. For these reasons, I stopped taking it and will try something else

Report this postFill 3Created with Sketch.
Anonymous | 55-64 | Female | Patient
8/17/2019
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 1.3
Effectiveness
Ease of Use
Satisfaction

I have taken this drug for 1 month now and it has not helped at all with the vaginal dryness, at week 2 I started noticing thick vaginal discharge which has now turned into a full blown yeast infection. Also experiencing diarrhea and nausea, I am stopping this medication, not worth the side effects. I had a total hysterectomy 15 years ago at 45... if this is the best science has to offer, I’ll just deal with the dryness.

Report this postFill 3Created with Sketch.
LB1010 | 55-64 | On medication for 6 months to less than 1 year | Patient
4/30/2019
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 4.7
Effectiveness
Ease of Use
Satisfaction

What a difference ! I can have sexagesimal itâ??s no pain! It worked fast too, within a month! My only issues is I get HOT flashes like never before! I feel like Iâ??m burning up....the it ease off,but itâ??s so uncomfortable! Wondering if anyone else has this? Iâ??ve cut back to 3 a week to see if it still works and maybe lessons the heat, so far,it has not!

Report this postFill 3Created with Sketch.
Irishmom74 | 45-54 | On medication for less than 1 month | Patient
4/28/2019
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 1.7
Effectiveness
Ease of Use
Satisfaction

I have BRCA 1. I had a total hysterectomy. My doctor recommended this drug. It worked like it has stated, but I was taking CBD oil for hot flashes. I have more hot flashes, anxiety is so bad and depression is mixed in there. I am getting headaches if I forget to take it in time. I am emotional wreck! Seeing my doctor on May 1st.

Report this postFill 3Created with Sketch.
Anonymous | 65-74 | Female | On medication for 1 to less than 2 years | Patient
4/9/2019
Condition: Vaginal Inflammation due to Loss of Hormone Stimulation
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction
Report this postFill 3Created with Sketch.
cindy j | 55-64 | Female | On medication for 2 to less than 5 years | Patient
3/13/2019
Condition: Other
Overall rating 5.0
Effectiveness
Ease of Use
Satisfaction

I have stress incontinence and had the surgery for a sling to repair the problem when I was 48. After menopause the incontinence returned. I have been on ospene for 3 years and the stress incontinence is once again under control. Best thing ever not to have to worry about peeing your pants while exercising.

Report this postFill 3Created with Sketch.
Disillusioned | 65-74 | On medication for 6 months to less than 1 year | Patient
3/8/2019
Condition: Painful Sexual Intercourse due to Menopause
Overall rating 2.3
Effectiveness
Ease of Use
Satisfaction

I chose this drug as I didnâ??t want another cream. Read the side effects and never saw anything about weight gain or itching or rash. I have been on in for over 6 months now and after reading what other women are experiencing I am going to finishing this bottle and may take 1/2 the dosage until completed. I gave put on weight, am terribly bloated all the time and recently broke out in a rash like acne. I would rather use an OTC liquid than this experience. I only wish I could get my money back for my last refill which was almost $90.Read More Read Less

Report this postFill 3Created with Sketch.

IMPORTANT INFORMATION ABOUT USER-GENERATED CONTENT ON WEBMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.

Read More