5HT-1D Agonists/SSRIs; SNRIs
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines may increase the level of serotonin in your body.
What might happen:
High serotonin levels may cause changes in body temperature, blood pressure and behavior, leading to a medical condition called Serotonin Syndrome. Serotonin Syndrome may be life threatening.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you experience muscle twitching, tremors, shivering and stiffness, fever, heavy sweating, heart palpitation, restlessness, confusion, agitation, trouble with coordination, or severe diarrhea contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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5.Imitrex Nasal Spray (sumatriptan) US prescribing information. GlaxoSmithKline March, 2012.
6.Amerge (naratriptan) US prescribing information. GlaxoSmithKline March, 2012.
7.Maxalt (rizatriptan) US prescribing information. Merck & Co., Inc. December, 2011.
8.Zomig (zolmitriptan) US prescribing information. AstraZeneca Pharmaceuticals LP September, 2012.
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10.Effexor (venlafaxine hydrochloride) US prescribing information. Wyeth Pharmaceuticals December, 2012.
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12.Prozac (fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company January, 2013.
13.Symbyax (olanzapine and fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company January, 2013.
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