Hydantoins/Omeprazole
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process your seizure medicine properly.
What might happen:
The blood levels of your seizure medicine may increase.
What you should do about this interaction:
If you experience nausea, vomiting, confusion, dizziness, or other symptoms, contact your doctor. It may be necessary to check your blood levels more often or to change the dose of your medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Prichard PJ, Walt RP, Kitchingman GK, Somerville KW, Langman MJ, Williams J, Richens A. Oral phenytoin pharmacokinetics during omeprazole therapy. Br J Clin Pharmacol 1987 Oct;24(4):543-5.
2.Gugler R, Jensen JC. Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. Gastroenterology 1985 Dec;89(6):1235-41.
3.Andersson T, Lagerstrom PO, Unge P. A study of the interaction between omeprazole and phenytoin in epileptic patients. Ther Drug Monit 1990 Jul; 12(4):329-33.
4.Jensen JC, Gugler R. Inhibition of human liver cytochrome P-450 by omeprazole. Br J Clin Pharmacol 1986 Mar;21(3):328-30.
