Ado-trastuzumab Emtansine/Strong CYP3A4 Inhibitors
How the interaction occurs:
Your medicine may slow down how quickly your body processes your chemotherapy medicine.
What might happen:
The amount of chemotherapy medicine in your blood may increase and cause more side effects than expected and some expected side effects to be more severe.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine or the timing of your chemotherapy. Let your doctor know right away if you experience nausea, vomiting, abdominal pain (especially in the right upper area of your abdomen), yellowing of the eyes or skin, dark urine, itching, loss of appetite, shortness of breath, coughing, swelling of the ankles/legs, rapid/fast/irregular heartbeat, dizziness, loss of consciousness,or if you gain more than 5 pounds in 24 hours.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Kadcyla (ado-trastuzumab emtansine) US prescribing information. Genentech, Inc. February, 2013.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.