Itraconazole; Ketoconazole/Selected 3A4 Inhibitors
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may slow down how quickly your liver processes itraconazole and ketoconazole. Itraconazole and ketoconazole may slow down how quickly your liver processes ritonavir and may speed up how quickly your liver processes lopinavir.
What might happen:
The amount of itraconazole and ketoconazole in your blood may increase and cause side effects. You may notice more side effects from your ritonavir as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to decrease the dose of itraconazole and ketoconazole. Let your doctor know if you have nausea, yellowing of the eyes or skin, unusual weakness, dark urine, pale stools, numbness or tingling of the hands or feet, depression, trouble breathing, or swelling of the ankles or feet.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir) prescribing information. Gilead Sciences, Inc. October, 2013.
2.Prezista (darunavir) US prescribing information. Tibotec Inc. November, 2013.
3.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline February, 2013.
4.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.
5.Ketek (telithromycin) US prescribing information. Sanofi-Aventis U.S. LLC December, 2010.
6.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. February, 2012.
7.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.
8.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals July 25, 2013.