Ergot Alkaloid Derivatives/Posaconazole; Voriconazole
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your antifungal medicine may slow down how quickly your body processes medicines that are related to the ergot alkaloid family.
What might happen:
The amount of ergot alkaloid in your blood may increase. Blood flow to your extremities (arms, legs, and face) may decrease.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these medicines together. Your doctor may want to change your medicine. If you experience chest pain; change in heartbeat; numbness and tingling of your hands, feet, or face; pain in your arms, legs, or lower back; itching; or other symptoms while taking these medicines together, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. February 2, 2006.
2.Noxafil (posaconazole) US prescribing information. Schering Corporation June, 2012.
3.Vfend (voriconazole) US prescribing information. Pfizer Inc. November, 2011.
4.Methergine (methylergonovine maleate) US prescribing information. Novartis Pharmaceuticals Corporation June, 2012.