Afatinib/Selected P-glycoprotein (P-gp) Inhibitors
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your medicine may cause your body to absorb more afatinib than expected.
What might happen:
The levels of afatinib in your blood may increase and cause more side effects than expected. You should watch for signs of skin rash, blisters or peeling, worsening diarrhea, shortness of breath, or fever.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you experience skin rash, blisters or peeling, shortness of breath, fever or increased diarrhea. Your doctor may want to decrease the dose of your afatinib or change your other medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Gilotrif (afatinib) prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. July, 2013.
2.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..