Fexofenadine/Fruit Juices
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Medical warning:
Important. Possible changes in your diet, medicine, or dosage should be discussed with your doctor or pharmacist.
How the interaction occurs:
Apple, grapefruit, and orange juice may prevent your body from absorbing your fexofenadine.
What might happen:
The amount of fexofenadine in your blood may decrease and it may not work as well.
What you should do about this interaction:
Try to avoid taking your fexofenadine with apple, grapefruit, or orange juice. If possible, take it with water instead.Contact your healthcare professional (e.g., doctor or pharmacist) for more information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.
References:
1.Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, Kim RB. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002 Jan;71(1):11-20.
2.Allegra (fexofenadine hydrochloride) US prescribing information. Sanofi-Aventis U.S. LLC October, 2006.
