Sensitive CYP3A4; CYP2C9; CYP2C19 Substrates/Enzalutamide
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Enzalutamide may speed up how quickly your body processes your medicine.
What might happen:
The amount of the other medicine in your blood may decrease and it may not work as well.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if your medicine does not seem to be working as well. Your doctor may want to check the amount of medicine in your blood, change its dose, or change your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Xtandi (enzalutamide) US prescribing information. Astellas Pharma US, Inc. August, 2012.
2.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2013..
3.Xtandi (enzalutamide) Canadian prescribing information. Astellas May 28, 2013.