Cyclosporine/Barbiturates (mono deleted 11/01/2012)
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process cyclosporine more quickly.
What might happen:
Your blood levels of cyclosporine may decrease and reduce the beneficial effects of cyclosporine.
What you should do about this interaction:
Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these drugs together, the dose of your cyclosporine may need adjusting. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Ptachcinski RJ, Venkataramanan R, Rosenthal JT, Burckart GJ, Taylor RJ, Hakala TR. Cyclosporine kinetics in renal transplantation. Clin Pharmacol Ther 1985 Sep;38(3):296-300.
2.Carstensen H, Jacobsen N, Dieperink H. Interaction between cyclosporin A and phenobarbitone. Br J Clin Pharmacol 1986 May;21(5):550-1.
3.Noguchi M, Kiuchi C, Akiyama H, Sakamaki H, Onozawa Y. Interaction between cyclosporin A and anticonvulsants. Bone Marrow Transplantation Team. Bone Marrow Transplant 1992 May;9(5):391.
