Cabazitaxel; Docetaxel; Paclitaxel/Strong CYP3A4 Inhibitors
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your other medicine may slow down how quickly your liver processes your cancer medicine.
What might happen:
The amount of cancer medicine in your blood may increase and it may cause more side effects than expected.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your cancer medicine while you are taking your other medicine. Let your doctor know right away if you develop any signs of an infection such as fever, chills, or a cough; numbness, tingling, or burning in your hands and/or feet; any unusual swelling.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Jevtana (cabazitaxel) US prescribing information. Sanofi-Aventis U.S. LLC March, 2014.
2.Taxotere (docetaxel) US prescribing information. Sanofi-Aventis U.S. LLC December, 2013.
3.Taxol (paclitaxel) US prescribing information. Bristol-Myers Squibb Company August, 2010.
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12.Koolen SL, Oostendorp RL, Beijnen JH, Schellens JH, Huitema AD. Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer. Br J Clin Pharmacol 2010 May;69(5):465-74.
13.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/ DrugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.
14.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..