Cabazitaxel; Docetaxel/Selected Protease Inhibitors (mono deleted 11/07/2013)
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your protease inhibitor may slow down how quickly your liver processes your cancer medicine.
What might happen:
The amount of your cancer medicine in your blood may increase and it may cause more side effects than expected.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your medicine. Let your doctor know right away if you develop any signs of an infection such a fever, chills, or a cough; numbness, tingling, or burning in your hands and/or feet; any unusual swelling.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Jevtana (cabazitaxel) US prescribing information. Sanofi-Aventis U.S. LLC June, 2010.
2.Taxotere (docetaxel) US prescribing information. Sanofi-Aventis U.S. LLC May, 2010.
3.Oostendorp RL, Huitema A, Rosing H, Jansen RS, Ter Heine R, Keessen M, Beijnen JH, Schellens JH. Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors. Clin Cancer Res 2009 Jun 15;15(12):4228-33.
4.Mir O, Dessard-Diana B, Louet AL, Loulergue P, Viard JP, Langlois A, Durdux C, Le Beller C. Severe toxicity related to a pharmacokinetic interaction between docetaxel and ritonavir in HIV-infected patients. Br J Clin Pharmacol 2010 Jan;69(1):99-101.
5.Loulergue P, Mir O, Allali J, Viard JP. Possible pharmacokinetic interaction involving ritonavir and docetaxel in a patient with Kaposi's sarcoma. AIDS 2008 Jun 19;22(10):1237-9.
6.Koolen SL, Oostendorp RL, Beijnen JH, Schellens JH, Huitema AD. Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer. Br J Clin Pharmacol 2010 May;69(5):465-74.