Cyclosporine/Carbamazepine (mono deleted 11/01/2012)
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process cyclosporine more quickly.
What might happen:
Your blood levels of cyclosporine may decrease. This may reduce the beneficial effects of cyclosporine.
What you should do about this interaction:
Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these two medicines together, it may be necessary to check your blood levels of cyclosporine more often. Your dose of cyclosporine may need adjusting. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Schofield OM, Camp RD, Levene GM. Cyclosporin A in psoriasis: interaction with carbamazepine. Br J Dermatol 1990 Mar;122(3):425-6.
2.Lele P, Peterson P, Yang S, Jarrell B, Burke JF Jr. Cyclosporine and tegretrol -- another drug interaction. Kidney Int 1985;27(1):344.
3.Soto Alvarez J, Sacristan Del Castillo JA, Alsar Ortiz MJ. Effect of carbamazepine on cyclosporin blood level. Nephron 1991;58(2):235-6.
4.Cooney GF, Mochon M, Kaiser B, Dunn SP, Goldsmith B. Effects of carbamazepine on cyclosporine metabolism in pediatric renal transplant recipients. Pharmacotherapy 1995 May-Jun;15(3):353-6.
