Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process etoposide properly.
What might happen:
An increase in the toxic effects of etoposide may occur. Additional problems may develop if you have kidney or liver conditions.
What you should do about this interaction:
Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of the interaction and may be monitoring you for it. If your doctor prescribes these medicines together, you may need to have your white blood cell counts monitored. If you develop a persistent sore throat or fever; black, tarry stools; or blood in urine or stools, contact your doctor as soon as possible. The dose of your medicines may need adjusting. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Lum BL, Kaubisch S, Yahanda AM, Adler KM, Jew L, Ehsan MN, Brophy NA, Halsey J, Gosland MP, Sikic BI. Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance. J Clin Oncol 1992 Oct;10(10):1635-42.