Ponatinib/Strong CYP3A4 Inducers
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Carbamazepine, mitotane, phenobarbital, phenytoin, rifabutin, rifampin and St. John's Wort may speed up how quickly your liver processes ponatinib.
What might happen:
Your ponatinib may not work as well while you are taking, and for 2 to 4 weeks after you stop taking, these other medicines.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have been taking carbamazepine, mitotane, phenobarbital, phenytoin, rifabutin, rifampin or St. John's Wort within 4 weeks of starting ponatinib therapy.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Iclusig (ponatinib) US prescribing information. ARIAD Pharmaceuticals Inc. December, 2013.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.