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Diflucan oral

Ospemifene/Fluconazole; Voriconazole

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Fluconazole or voriconazole may slow down how quickly your body processes ospemifene.

What might happen:

The amount of medicine in your blood may increase and cause more side effects than expected. If you take this medicine combination for an extended period of time, the lining of your uterus(womb) could thicken, increasing the risk for cancer of the uterus lining.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. They may want you to stop taking ospemifene while you are taking fluconazole or voriconazole. Contact your doctor as soon as possible if you have any unusual vaginal bleeding so they can find the cause.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Osphena (ospemifene) US prescribing information. Shionogi Incorporated February 26, 2013.
2.FDA. CDER Application number: 203505 Osphena (ospemifene), Clinical Pharmacology and Biopharmaceutics Review. URL: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203505Orig1s000Clin PharmR.pdf February 26, 2013.
3.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.

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