Cyclosporine/Nefazodone
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nefazodone may speed up how quickly your liver processes cyclosporine.
What might happen:
The amount of cyclosporine in your blood may increase and may harm your kidneys.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check the amount of cyclosporine in your blood and your kidney function more often while you are taking your antibiotic.Tell your doctor if you have any kidney problems. If you experience any shortness of breath, unusual swelling, changes in the color or amount of your urine, or changes in how often you urinate, contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Helms-Smith KM, Curtis SL, Hatton RC. Apparent interaction between nefazodone and cyclosporine. Ann Intern Med 1996 Sep 1;125(5):424.
2.Vella JP, Sayegh MH. Interactions between cyclosporine and newer antidepressant medications. Am J Kidney Dis 1998 Feb;31(2):320-3.
3.Wright DH, Lake KD, Bruhn PS, Emery RW Jr. Nefazodone and cyclosporine drug-drug interaction. J Heart Lung Transplant 1999 Sep;18(9):913-5.
