Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Voriconazole may slow down how quickly your liver processes sirolimus.
What might happen:
When sirolimus is taken with voriconazole, your blood levels of sirolimus may increase. This could be harmful to your kidneys.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
1.Vfend (voriconazole) US prescribing information. Pfizer Inc. November, 2011.
2.Rapamune (sirolimus) US prescribing information. Wyeth Pharmaceuticals March, 2013.
3.Mathis AS, Shah NK, Friedman GS. Combined use of sirolimus and voriconazole in renal transplantation: a report of two cases. Transplant Proc 2004 Nov;36(9):2708-9.
4.Sadaba B, Campanero MA, Quetglas EG, Azanza JR. Clinical relevance of sirolimus drug interactions in transplant patients. Transplant Proc 2004 Dec;36(10):3226-8.