Selected Azole Antifungals/Boceprevir; Telaprevir
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your HIV medicine and your antifungal medicine may slow down how quickly your liver processes each other.
What might happen:
The amount of medicine in your blood may increase and cause side effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to decrease the dose of itraconazole and ketoconazole. Let your doctor know if you have nausea, yellowing of the eyes or skin, unusual weakness, dark urine, pale stools, numbness or tingling of the hands or feet, depression, trouble breathing, or swelling of the ankles or feet.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Victrelis (boceprevir) US prescribing information. Schering Corporation February, 2013.
2.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated April, 2013.
3.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.