Ponatinib/Strong CYP3A4 Inhibitors
How the interaction occurs:
Some medicines may slow down how quickly your body processes ponatinib.
What might happen:
The amount of ponatinib in your blood may increase and cause more or more severe side effects than expected.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust the dose of your ponatinib while you are taking your other medicine. Let your doctor know right away if you develop any unusual bleeding, bruising, fatigue, shortness of breath, palpitations, chest pain, chills, fever, abdominal pain, nausea, vomiting, weakness, or a painful skin rash/blisters.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Iclusig (ponatinib) US prescribing information. ARIAD Pharmaceuticals Inc. December, 2012.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.