Bedaquiline/Strong CYP3A4 Inhibitors
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines can slow down how quickly your body processes bedaquiline.
What might happen:
The amount of bedaquiline in your blood may increase and cause more side effects than expected, including problems with your liver and changes to your heart rhythm, which may be life-threatening.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine and/or perform an electrocardiogram (ECG). Let your doctor know right away if you notice and irregular heartbeat or have any dizziness or fainting episodes or if you develop unexplained nausea or vomiting, stomach pain, fever, weakness, itching, unusual tiredness, loss of appetite, light colored bowel movements, dark colored urine, or yellowing of the skin or whites of your eyes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Sirturo (bedaquiline) US prescribing information. Janssen Therapeutics August, 2013.
2.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.