Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Fluvoxamine may slow down how quickly your liver processes ramelteon.
What might happen:
The amount of ramelteon in your blood may increase and cause more side effects than normally expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Let your doctor know if you have excessive drowsiness, dizziness, fatigue, nausea, depression, muscle pain, or if your insomnia gets worse.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Rozerem (ramelteon) US prescribing information. Takeda Pharmaceuticals America Inc. November, 2010.
2.Luvox (fluvoxamine maleate) US prescribing information. ANI Pharmaceuticals November, 2012.
3.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.