Astemizole; Terfenadine/SSRIs; Nefazodone
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process your antihistamine more slowly.
What might happen:
The blood levels of your antihistamine may increase and cause life-threatening effects to your heart.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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2.Serzone (nefazodone hydrochloride) US prescribing information. Bristol-Myers Squibb Company January, 2005.
3.Seldane (terfenadine) US prescribing information. Hoechst-Marion Roussel September, 1997.
4.Hismanal (astemizole) US prescribing information. Janssen Pharmaceutica Products, L.P. February, 1998.
5.Prozac (fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company January, 2013.
6.Paxil (paroxetine hydrochloride) US prescribing information. GlaxoSmithKline December, 2012.
7.Pexeva (paroxetine mesylate) US prescribing information. Noven Therapeutics, LLC December, 2012.
8.Zoloft (sertraline) US prescribing information. Pfizer Inc. December, 2012.