Sertraline/Grapefruit Juice Interaction
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Important. Possible changes in your diet, medicine, or dosage should be discussed with your doctor or pharmacist.
How the interaction occurs:
Grapefruit juice decreases the ability of the gut to process sertraline.
What might happen:
The level of this drug can increase in your blood. This might lead to sleepiness, nausea, nervousness and increased heart rate.
What you should do about this interaction:
While you are taking this medicine, you should avoid eating grapefruit or drink grapefruit juice. You may choose an alternative citrus beverage (such orange juice).In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juic you should immediately discuss with doctor the effects of grapefruit on the blood levels of this medicine. If you notice an increase in any side effect from your medicine, such as sleepiness, nausea, nervousness, or increased heart rate, contact your doctor.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.
1.Miniscalco A, Lundahl J, Regardh CG, Edgar B, Eriksson UG. Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J Pharmacol Exp Ther 1992 Jun;261(3):1195-9.
2.Lee AJ, Chan WK, Harralson AF, Buffum J, Bui BC. The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study. Clin Ther 1999 Nov;21(11):1890-9.