Atomoxetine/Strong 2D6 Inhibitors
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Bupropion, cinacalcet, fluoxetine, paroxetine, and quinidine may slow down how quickly your liver processes atomoxetine.
What might happen:
The amount of atomoxetine in your blood may increase and cause more side effects than normal. Side effects may include increased blood pressure, faster heart rate, irritability, nausea, vomiting, or decreased appetite.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust the dose of your atomoxetine. Let your doctor know if you have any side effects from your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.
2.Strattera (atomoxetine hydrochloride) US prescribing information. Eli Lilly and Company August, 2012.
3.Pexeva (paroxetine mesylate) US prescribing information. Noven Therapeutics, LLC December, 2012.
4.Belle DJ, Ernest CS, Sauer JM, Smith BP, Thomasson HR, Witcher JW. Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics. J Clin Pharmacol 2002 Nov;42(11):1219-27.