How the interaction occurs:
Both cyclosporine and methotrexate affect your immune system. Cyclosporine may also slow down how quickly your body processes methotrexate.
What might happen:
The amount of methotrexate in your blood may increase and cause more side effects than normal. You may also have a greater risk of developing cancer.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and why you are taking these medicines. These medicines are not normally used together to treat psoriasis, but are used together to treat rheumatoid arthritis (RA). Your doctor may want to perform laboratory tests on you monthly to check your blood and your liver. Be sure to keep all of your laboratory appointments.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Fox RI, Morgan SL, Smith HT, Robbins BA, Choc MG, Baggott JE. Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone. Rheumatology (Oxford) 2003 Aug;42(8):989-94.
2.Neoral (cyclosporine) US prescribing information. Novartis Pharmaceuticals Corporation May, 2013.
3.Baraldo M, Ferraccioli G, Pea F, Gremese E, Furlanut M. Cyclosporine A pharmacokinetics in rheumatoid arthritis patients after 6 months of methotrexate therapy. Pharmacol Res 1999 Dec;40(6):483-6.