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Sandimmune oral

Cyclosporine/Rifamycins (mono deleted 11/01/2012)

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process cyclosporine more quickly.

What might happen:

Your blood levels of cyclosporine may decrease.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Langhoff E, Madsen S. Rapid metabolism of cyclosporin and prednisone in kidney transplant patient receiving tuberculostatic treatment. Lancet 1983 Oct 29;2(8357):1031.
2.Van Buren D, Wideman CA, Ried M, Gibbons S, Van Buren CT, Jarowenko M, Flechner SM, Frazier OH, Cooley DA, Kahan BD. The antagonistic effect of rifampin upon cyclosporine bioavailability. Transplant Proc 1984 Dec; 16(6):1642-5.
3.Daniels NJ, Dover JS, Schachter RK. Interaction between cyclosporin and rifampicin. Lancet 1984 Sep 15;2(8403):639.
4.Allen RD, Hunnisett AG, Morris PJ. Cyclosporin and rifampicin in renal transplantation. Lancet 1985 Apr 27;1(8435):980.
5.Howard P, Bixler TJ, Gill B. Cyclosporine-rifampin drug interaction. Drug Intell Clin Pharm 1985 Oct;19(10):763-4.
6.Anonymous. Cyclosporin and antituberculous therapy. Lancet 1985 Jun 8; 1(8441):1342-3.
7.Cassidy MJ, Van Zyl-Smit R, Pascoe MD, Swanepoel CR, Jacobson JE. Effect of rifampicin on cyclosporin A blood levels in a renal transplant recipient. Nephron 1985;41(2):207-8.
8.Offermann G, Keller F, Molzahn M. Low cyclosporin A blood levels and acute graft rejection in a renal transplant recipient during rifampin treatment. Am J Nephrol 1985;5(5):385-7.
9.al-Sulaiman MH, Dhar JM, al-Khader AA. Successful use of rifampicin in the treatment of tuberculosis in renal transplant patients immunosuppressed with cyclosporine. Transplantation 1990 Oct;50(4):597-8.
10.Vandevelde C, Chang A, Andrews D, Riggs W, Jewesson P. Rifampin and ansamycin interactions with cyclosporine after renal transplantation. Pharmacotherapy 1991;11(1):88-9.
11.Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin Pharmacol Ther 1992 Nov; 52(5):453-7.

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