Skip to content

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt

    Ask your HCP about a nonsurgical treatment option

    This content is from our sponsor. The sponsor has sole editorial control.

    WONDERING IF XIAFLEX® is RIGHT FOR YOU?

    LEARN MORE ABOUT A NONSURGICAL TREATMENT

    What is XIAFLEX®?

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. XIAFLEX® is injected directly into the "cord" that is causing your finger to be bent.

    Injection of XIAFLEX® and the finger extension procedure can be performed:

    FIND SPECIALISTS NEAREST YOU

    ENTER YOUR ZIP CODE

    • In your healthcare professional's (HCPs) office
    • By a hand specialist with training specifically for XIAFLEX®
    • With no general anesthesia required

    XIAFLEX® should be injected into a "cord" by a specialist who is experienced in injection procedures of the hand and treating people with Dupuytren's contracture. XIAFLEX® can cause serious side effects such as tendon rupture or ligament damage.

    How XIAFLEX® works

    The enzymes in XIAFLEX® may break down the collagen in the "cord". At a follow-up visit 1 to 3 days after the injection, if you still have the "cord", your HCP may try to extend the finger to "break" the "cord" and try to straighten your finger. Your HCP may use local anesthetic during this procedure. Your HCP may prescribe treatment with XIAFLEX® if you have:

    • Contractures ranging from less severe to more severe
    • Multiple contractures in 1 hand. Up to 2 cords in 1 hand may be treated during 1 office visit
    • Contractures that have come back

    Demonstrated in clinical studies

    Studies show that prescription XIAFLEX® along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.

    In 2 clinical studies, 64% and 44% of people receiving XIAFLEX® (vs 7% and 5% of patients receiving placebo) had a straight or nearly straight finger after up to 3 XIAFLEX® injection procedures.

    WHAT IS XIAFLEX®?

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

    IMPORTANT SAFETY INFORMATION FOR XIAFLEX®

    Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

    XIAFLEX® can cause serious side effects, including:

    • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
    • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
    • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
      • hives
      • swollen face
      • breathing trouble
      • chest pain
      • low blood pressure
      • dizziness or fainting
    • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

    Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

    The most common side effects with XIAFLEX® for the treatment of Dupuytren's contracture include:

    • swelling of the injection site or the hand
    • bruising or bleeding at the injection site
    • pain or tenderness of the injection site or the hand
    • swelling of the lymph nodes (glands) in the elbow or armpit
    • itching
    • breaks in the skin
    • redness or warmth of the skin
    • pain in the armpit

    Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

    Please see the full Prescribing Information, including Medication Guide.

    The information on this website should not take the place of talking with your doctor. If you have any questions, talk to your doctor or pharmacist.

    WebMD does not endorse any specific product, service, or treatment.

    Important Safety Information | Full Prescribing Information | Medication Guide

    IMPORTANT SAFETY INFORMATION FOR XIAFLEX®

    Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®.

    XIAFLEX® can cause serious side effects, including:

    • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX® may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
    • Nerve injury or other serious injury of the hand. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
    • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX® because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX®:
      • hives
      • swollen face
      • breathing trouble
      • chest pain
      • low blood pressure
      • dizziness or fainting
    • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX®. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX® may not be right for you.

    Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX® with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

    The most common side effects with XIAFLEX® for the treatment of Dupuytren's contracture include:

    • swelling of the injection site or the hand
    • bruising or bleeding at the injection site
    • pain or tenderness of the injection site or the hand
    • swelling of the lymph nodes (glands) in the elbow or armpit
    • itching
    • breaks in the skin
    • redness or warmth of the skin
    • pain in the armpit

    Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

    WHAT IS XIAFLEX®?

    XIAFLEX® is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX® is safe and effective in children under the age of 18.

    Please see the full Prescribing Information, including Medication Guide.

    The information on this website should not take the place of talking with your doctor. If you have any questions, talk to your doctor or pharmacist.

    This product information is intended for U.S. residents only.

    Rx Only

    XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates.

    © 2017 Endo Pharmaceuticals Inc.

    All rights reserved. Malvern, PA 19355

    XD-05030/January 2017 www.xiaflex.com 1-800-462-ENDO (3636)