Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Epilepsy Health Center

Font Size

Epilepsy Drug Linked to Birth Defects, Low IQ

Evidence Continues to Mount Against Valproate

No Increase Seen With Lamictal continued...

The study included 414 women who took the drug, either alone or in combination with valproate, during their first trimester of pregnancy between 1992 and 2004.

Roughly 3% of the children born to women who took Lamictal alone had birth defects -- a rate that is similar to that seen in the general population. Four times as many birth defects were reported among women who took Lamictal with valproate.

Several other studies also suggest that newer epilepsy drugs like Lamictal carry a low risk for birth defects. But neurologist Patricia Penovich, MD, tells WebMD that the research is far from conclusive.

"We simply don't have enough information to say with scientific certainty that these newer drugs are safe," she says.

The issue is further complicated by the fact that for many patients with epilepsy, valproate may be the only drug that works to control seizures.

"The most important thing that we can do for a mother is to keep her from having seizures during pregnancy," Penovich says.

French says there is a huge need for new drugs that work as well as valproate without the risks.

"Valproate is very effective for many (types of epilepsy), and there really is not a clear alternative drug for many women at this moment," she says.

But both neurologists agree that too many at-risk women who could control their seizures with other medications are still taking valproate. As many as 15 million prescriptions for antiseizure drugs are written each year to women in their childbearing years.

Folic Acid a Remedy?

There is some evidence that valproate users can lower their risk by taking large amounts of folic acid. It is generally recommended that women who are pregnant or might become pregnant take 400 micrograms of the vitamin. Some experts recommend 10 times that amount for women on the epilepsy drug.

But French says the evidence proving that folic acid can protect babies exposed to valproate in the womb has not materialized.

"Unfortunately, the data haven't shown this to be the case," she says.

Penovich says the risk for the mother and the child can be minimized by carefully planning seizure therapy prior to pregnancy, by supplementing with folate, and by using one seizure drug (rather than numerous drugs) at the lowest and most effective dose.

1 | 2

Today on WebMD

human head and brain waves
Causes, symptoms, and treatments.
Grand mal seizure
How is each one different?
marijuana plant
CBD, a plant chemical, may cut down seizures.
prescription bottle
Which medication is right for you?
Seizures Driving
Questions for Doctor Epilepsy
Graces Magic Diet
Pills spilling from bottle in front of clock
first aid kit
Caring Child Epilepsy
Making Home Safe
epilepsy monitoring

WebMD Special Sections