Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Epilepsy Health Center

Font Size

Birth Defects Linked to Valproic Acid

6 Birth Defects More Common in Pregnant Women Who Take Epilepsy Drug
WebMD Health News
Reviewed by Laura J. Martin, MD

June 9, 2010 -- Women with epilepsy who take valproic acid during the first trimester of pregnancy are more likely to have children with birth defects than women who took other epilepsy drugs or no medicine to control their seizures during pregnancy.

The findings appear in the June 10 issue of the New England Journal of Medicine.

Valproic acid is also used to treat other illnesses, including bipolar disorder and migraines. Brand names include Depakote, Depakene, Depacon, and Stavzor.

Almost 3 million people in the U.S. have some form of epilepsy, according to the Epilepsy Foundation.

“Our findings provide further support for the recommendation of the American Academy of Neurology to avoid the use of valproic acid, if possible, in pregnant women,” conclude the researchers, who were led by Janneke Jentink, MSc, of the University of Groningen in Groningen, Netherlands. “Since switching drugs during or just before pregnancy is difficult, the risks associated with valproic acid use should be routinely considered in choosing therapy for women with childbearing potential.”

The researchers reviewed data from eight studies that highlighted 14 birth defects that were more common among offspring of women who took this epilepsy drug during the first trimester. Next, they identified infants with these 14 birth defects from the European Surveillance of Congenital Anomalies (EUROCAT) antiepileptic-study database, and compared them to a group of infants with birth defects not previously connected to use of this drug and to a group of infants with chromosomal abnormalities.

6 Birth Defects Linked to Valproic Acid

The researchers found that six birth defects were more common among children of women who took valproic acid during first trimester than children of women who did not take antiseizure drugs:

  1. Spina bifida
  2. Atrial septal defect (a hole in the heart)
  3. Cleft palate
  4. Hypospadias (an abnormality in the opening of the urethra in boys)
  5. Polydactyly (extra fingers or toes)
  6. Craniosynostosis (one or more sutures on a baby’s skull close prematurely)

When compared with other epilepsy drugs, valproic acid increased the risk for all of these birth defects except craniosynostosis, the study showed. It also showed an increased risk of ventricular septal defect (a hole in the heart) when compared to other epilepsy drugs.

1 | 2 | 3

Today on WebMD

human head and brain waves
Causes, symptoms, and treatments.
Grand mal seizure
How is each one different?
marijuana plant
CBD, a plant chemical, may cut down seizures.
prescription bottle
Which medication is right for you?
Seizures Driving
Questions for Doctor Epilepsy
Graces Magic Diet
Pills spilling from bottle in front of clock
first aid kit
Caring Child Epilepsy
Making Home Safe
epilepsy monitoring

WebMD Special Sections