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    Precautions Cut Sudden Death Risk of Epilepsy

    Analysis Shows Reducing the Number of Seizures and Taking Medicine as Prescribed Can Reduce Risk
    WebMD Health News
    Reviewed by Louise Chang, MD

    July 5, 2011 -- People with epilepsy who are otherwise healthy are known to have a risk of unexplained sudden death that is more than 20 times higher than the general population. Doctors call it sudden unexpected death in epilepsy or SUDEP.

    However, that risk may be reduced by a variety of precautions, a new review of research finds.

    The review, published online in The Lancet, should be understood properly by those with epilepsy, says researcher Simon Shorvon, MD, professor of neurology at University College London. "Life is full of risks," he says, ''and [it's] important to keep in perspective. "

    For the review, Shorvon searched for published medical studies focusing on the seizure disorder epilepsy and sudden death from 1950 to 2010, finding 580 articles. He focused on those published in the past five years.

    About 3 million Americans have epilepsy and seizures, according to the Epilepsy Foundation.

    How to Reduce Risk of Sudden Death

    Shorvon pooled the data from his analysis of risk factors. He found:

    • The more often a seizure known as tonic-clonic occurs, the higher the risk. These are a type of generalized seizure that affects the entire brain.
    • Men were at higher risk than women.
    • Those who had epilepsy long term were at higher risk than those who had it for a shorter time.
    • Those on many epilepsy medicines were at higher risk than those not taking many medicines.

    Shorvon also found SUDEP usually occurs when people with epilepsy are not observed by others and often at night.

    To reduce risk, ''reducing the number of convulsions is probably the single most important way of prevention [of SUDEP],'' Shorvon tells WebMD.

    Other ways to reduce risk:

    • Take medication as prescribed.
    • If drugs are changed, the doctor should change them in a gradual manner.
    • Patients at high risk should be supervised at night. A person can supervise the patient or the patient can use alarms that are set off by seizures.
    • Epilepsy drugs that have potential cardiac and respiratory effects should be prescribed with care.  
    • Doctors should discuss risks of sudden death with people with epilepsy.

    The measures suggested to reduce SUDEP risk are only speculative suggestions, Shorvon writes, based on data about what leads to SUDEP. If medications don't help, Shorvon writes, epilepsy surgery can help make a patient seizure-free and probably reduces the risk of SUDEP.

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