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Erectile Dysfunction Health Center

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How Does Alprostadil Treat Erectile Dysfunction?

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How Do I Inject Alprostadil?

Your doctor will teach you how to give yourself the injection. If you need to prepare the mixture you’ll inject, follow the directions provided.

Before you draw the medicine into the syringe, wash your hands with soap and water. Set the bottles on a clean surface. Wipe the tops of the injection bottles with an alcohol swab.

After you mix a single dose, you must use it immediately. Throw away any unused mixture in the syringe. Don’t store it -- you cannot use it later on.

Throw out the needles. Do not reuse them!

If you have any questions about how to use this medication, ask your doctor or pharmacist.

How Do I Insert the Suppository?

First, urinate. The small amount of urine left in the urethra will help dissolve the suppository.

The suppository is about half the size of a grain of rice. You’ll insert it into the urethra (the opening at the end of the penis) using a plastic applicator.

You can use a small amount of lubricant like KY Jelly or Astroglide to help you insert the applicator. Push the button on the applicator to deliver the suppository into the urethra.

To help dissolve the suppository once inside, roll your penis between your hands for 10 seconds. If you feel any stinging, continue this motion to help that feeling stop.

Sit, stand, or walk for 10 minutes to boost blood flow to your penis to help with an erection.

If you have questions, ask your doctor or pharmacist.

How Do I Know Which One Is Right for Me?

Choosing between the injection and suppository is a personal choice. Talk to your doctor about the pros and cons. For example, the injection may be more painful, but it’s more effective than the suppository.


If you use alprostadil (either by injection or suppository) and have sex with a pregnant woman, use a condom. Doctors don’t know if alprostadil will affect the baby.

Store the drug in its original container, out of the reach of children. Follow the directions on the label about where it’s OK to store it. For instance, keep it out of warm, moist settings (such as the bathroom). If you keep it in your fridge, don’t let it freeze.

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