Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Erectile Dysfunction Health Center

Select An Article

How Does Alprostadil Treat Erectile Dysfunction?

Font Size

How Do I Inject Alprostadil?

Your doctor will teach you how to give yourself the injection. If you need to prepare the mixture you’ll inject, follow the directions provided.

Before you draw the medicine into the syringe, wash your hands with soap and water. Set the bottles on a clean surface. Wipe the tops of the injection bottles with an alcohol swab.

After you mix a single dose, you must use it immediately. Throw away any unused mixture in the syringe. Don’t store it -- you cannot use it later on.

Throw out the needles. Do not reuse them!

If you have any questions about how to use this medication, ask your doctor or pharmacist.

How Do I Insert the Suppository?

First, urinate. The small amount of urine left in the urethra will help dissolve the suppository.

The suppository is about half the size of a grain of rice. You’ll insert it into the urethra (the opening at the end of the penis) using a plastic applicator.

You can use a small amount of lubricant like KY Jelly or Astroglide to help you insert the applicator. Push the button on the applicator to deliver the suppository into the urethra.

To help dissolve the suppository once inside, roll your penis between your hands for 10 seconds. If you feel any stinging, continue this motion to help that feeling stop.

Sit, stand, or walk for 10 minutes to boost blood flow to your penis to help with an erection.

If you have questions, ask your doctor or pharmacist.

How Do I Know Which One Is Right for Me?

Choosing between the injection and suppository is a personal choice. Talk to your doctor about the pros and cons. For example, the injection may be more painful, but it’s more effective than the suppository.


If you use alprostadil (either by injection or suppository) and have sex with a pregnant woman, use a condom. Doctors don’t know if alprostadil will affect the baby.

Store the drug in its original container, out of the reach of children. Follow the directions on the label about where it’s OK to store it. For instance, keep it out of warm, moist settings (such as the bathroom). If you keep it in your fridge, don’t let it freeze.

Next Article:

Today on WebMD

handsome midadult man
11 tips to protect your erection.
man and woman on beach
How much do you know about ED?
stress in bed
Things that can deflate erections.
senior couple hugging
How medications work.
concerned man
stress in bed
Life Cycle of a Penis
Mens Body Problem
bored man
Lamm Erections Over Life
Food Men 10 Foods Boost Male Health
senior couple hugging

WebMD Special Sections